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S.E.M.I.: Side Effects May Include...

S.E.M.I.: Side Effects May Include...

|Arcade, Indie

8.6 /10

Aww Great!

Niche

112 ratings
Where to get it
Screenshots
Why play it

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Game highlights
Rating momentum

Aww Great!: 8.6/10 across 112 ratings. Word of mouth is strong — if you like the genre, go for it.

Play style

Leans into Arcade, Indie, Hack and Slash — a quick read on whether that fantasy matches what you usually enjoy.

Reviews

2 media reviews

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Marooners' RockBella Rose · 18 Mar, 2026
8/10

S.E.M.I.: Side Effects May Include delivers exactly what it promises: chaotic, unpredictable co-op fun. Whether you’re intentionally sabotaging your friends or accidentally laser-beaming your entire team off a platform, the game thrives on its physics-driven madness.

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TheBigBoisZachary Holmes · 2 Feb, 2026
6.5/10

S.E.M.I. – Side Effects May Include… is a solid budget party game. It isn't going to win Game of the Year, and it likely won't keep you occupied for weeks. But as a weekend distraction with friends? It’s a prescription worth filling. It is cute, chaotic, and derpy. Just be prepared for some bugs and maybe don't try to tackle it alone.

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